Features of the Reagent Proteins Haptoglobin Human:
Haptoglobin is a glycoprotein which is synthesized in the liver and circulates in the blood.
Haptoglobin is produced typically by hepatocytes but also by other tissues: e.g. skin, lung, and kidney.
It is a positive acute phase protein that binds free hemoglobin and removes it from the circulation to prevent kidney injury, and iron loss following hemolysis.
The haptoglobin-hemoglobin complex is subsequently removed by the reticuloendothelial system (generally the spleen). As the reticuloendothelial system removes the haptoglobin-hemoglobin complex from the body, haptoglobin levels are reduced in hemolytic anaemias.
In the course of binding hemoglobin, haptoglobin sequesters the iron inside hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis.
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